Epidemiology and Survival of Dogs Diagnosed with Splenic Lymphoid Hyperplasia, Complex Hyperplasia, Stromal Sarcoma and Histiocytic Sarcoma

Cleide H Spröhnle-Barrera, J. M., Rachel E Allavena, Helen C Owen, Chiara Palmieri, Tamsin S Barnes
08/04/2022

Dogs are frequently diagnosed with nodular lesions affecting the spleen. One of the most common lesions has been traditionally classified as fibrohistiocytic nodules but has more recently been separated into different types: lymphoid hyperplasia, complex hyperplasia, stromal sarcoma, and histiocytic sarcoma. Notably, there are contradictory reports on the survival times of dogs diagnosed with stromal sarcoma and histiocytic sarcoma. In addition, some studies have found an association between the diagnosis of these nodules with the dog’s age, breed, sex, and survival time. This paper aims to estimate the frequency of the previously known fibrohistiocytic nodules among splenectomized dogs and identify associations between the four different types of nodules with the age, sex, breed, and survival. Typical survival times varied markedly between the four types of nodules. These findings reveal widely different outcomes for dogs diagnosed with each fibrohistiocytic nodule, providing useful information to clinicians on the survival estimates of these lesions.

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Cleide H Spröhnle-Barrera, J. M., Rachel E Allavena, Helen C Owen, Chiara Palmieri, Tamsin S Barnes (2022). "Epidemiology and Survival of Dogs Diagnosed with Splenic Lymphoid Hyperplasia, Complex Hyperplasia, Stromal Sarcoma and Histiocytic Sarcoma." Animals 12(8): 960. https://doi.org/10.3390/ani12080960